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Target
ATP-sensitive inward rectifier potassium channel 1
Ligand
BDBM350313
Substrate
n/a
Meas. Tech.
Thallium Flux Assay
IC50
44.0±n/a nM
Citation
 Pasternak, A; Davies, I; Ding, F; Jiang, J; Dong, S; Gu, X; Suzuki, T; Vacca, JP; Pu, Z; Xu, S Inhibitors of the renal outer medullary potassium channel US Patent  US10208064 Publication Date 2/19/2019 
Target
Name:
ATP-sensitive inward rectifier potassium channel 1
Synonyms:
ATP-regulated potassium channel ROM-K | ATP-regulated potassium channel ROMK | ATP-sensitive inward rectifier potassium channel 1 | Egl nine homolog 1 | KCNJ1 | KCNJ1_HUMAN | Potassium channel (ATP modulatory) | Potassium inwardly-rectifying channel, subfamily J, member 1 | ROMK1 | Renal Outer Medullary Potassium (ROMK1) | The Renal Outer Medullary Potassium (ROMK)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44809.08
Organism:
Homo sapiens (Human)
Description:
gi_223460826
Residue:
391
Sequence:
MNASSRNVFDTLIRVLTESMFKHLRKWVVTRFFGHSRQRARLVSKDGRCNIEFGNVEAQSRFIFFVDIWTTVLDLKWRYKMTIFITAFLGSWFFFGLLWYAVAYIHKDLPEFHPSANHTPCVENINGLTSAFLFSLETQVTIGYGFRCVTEQCATAIFLLIFQSILGVIINSFMCGAILAKISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTVTPEGETIILDQININFVVDAGNENLFFISPLTIYHVIDHNSPFFHMAAETLLQQDFELVVFLDGTVESTSATCQVRTSYVPEEVLWGYRFAPIVSKTKEGKYRVDFHNFSKTVEVETPHCAMCLYNEKDVRARMKRGYDNPNFILSEVNETDDTKM
  
Inhibitor
Name:
BDBM350313
Synonyms:
(S)-8-(2-hydroxy-1-(tetrazolo[1,5-a]quinolin-7-yl)ethyl)-2-(4-methyl-5-oxo-2,5-dihydrofuran-3-yl)-2,8-diazaspiro[4.5]decan-1-one | US10208064, Example 28A
Type:
Small organic molecule
Emp. Form.:
C24H26N6O4
Mol. Mass.:
462.501
SMILES:
CC1=C(COC1=O)N1CCC2(CCN(CC2)[C@H](CO)c2ccc3c(ccc4nnnn34)c2)C1=O |r,t:1|
Structure:
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