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Target
N-formyl peptide receptor 2
Ligand
BDBM350690
Substrate
n/a
Meas. Tech.
FLIPR
EC50
12000±n/a nM
Citation
 Beard, RL; Donello, JE; Viswanath, V Use of agonists of formyl peptide receptor 2 for treating ocular inflammatory diseases US Patent  US10208071 Publication Date 2/19/2019 
Target
Name:
N-formyl peptide receptor 2
Synonyms:
ALXR, FPRL1, FPR2 | FMLP-related receptor I FMLP-R-I | FPR2 | FPR2_HUMAN | FPRH1 | FPRL1 | Formyl Peptide Receptor-Like 1 | HM63 | LXA4 receptor | LXA4R | Lipoxin A4 receptor | Lipoxin A4 receptor (LXA4) | RFP | hFPRL
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
38968.35
Organism:
Homo sapiens (Human)
Description:
P25090
Residue:
351
Sequence:
METNFSTPLNEYEEVSYESAGYTVLRILPLVVLGVTFVLGVLGNGLVIWVAGFRMTRTVTTICYLNLALADFSFTATLPFLIVSMAMGEKWPFGWFLCKLIHIVVDINLFGSVFLIGFIALDRCICVLHPVWAQNHRTVSLAMKVIVGPWILALVLTLPVFLFLTTVTIPNGDTYCTFNFASWGGTPEERLKVAITMLTARGIIRFVIGFSLPMSIVAICYGLIAAKIHKKGMIKSSRPLRVLTAVVASFFICWFPFQLVALLGTVWLKEMLFYGKYKIIDILVNPTSSLAFFNSCLNPMLYVFVGQDFRERLIHSLPTSLERALSEDSAPTNDTAANSASPPAETELQAM
  
Inhibitor
Name:
BDBM350690
Synonyms:
US10208071, Compound 153 | US10434112, Compound 153 | US10799518, Compound 153 | ethyl 3-{[(4- bromophenyl)carbamoyl]amino}- 2,4-dioxo-1,3- diazaspiro[4.5]decane-8- carboxylate
Type:
Small organic molecule
Emp. Form.:
C18H21BrN4O5
Mol. Mass.:
453.287
SMILES:
CCOC(=O)C1CCC2(CC1)NC(=O)N(NC(=O)Nc1ccc(Br)cc1)C2=O |(-8.54,-.56,;-7.05,-.96,;-6.65,-2.45,;-5.16,-2.84,;-4.77,-4.33,;-4.08,-1.76,;-4.47,-.27,;-3.39,.82,;-1.9,.42,;-1.5,-1.07,;-2.59,-2.15,;-2.37,1.89,;-1.13,2.79,;-1.13,4.33,;.12,1.89,;1.61,2.29,;2.69,1.2,;2.3,-.29,;4.18,1.6,;5.27,.51,;4.87,-.98,;5.96,-2.07,;7.45,-1.67,;8.54,-2.76,;7.85,-.18,;6.76,.9,;-.36,.42,;.41,-.91,)|
Structure:
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