Reaction Details Report a problem with these data
Target
Histone deacetylase 2
Ligand
BDBM207629
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1980±n/a nM
Citation
 Rusche, JR; Peet, NP; Hopper, A Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors US Patent  US9796664 Publication Date 10/24/2017 
Target
Name:
Histone deacetylase 2
Synonyms:
Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:
Chromatin regulator; hydrolase; repressor
Mol. Mass.:
55356.54
Organism:
Homo sapiens (Human)
Description:
Q92769
Residue:
488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKATAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAGAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQIFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLGGGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYMEKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEEFSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGTKSEQLSNP
  
Inhibitor
Name:
BDBM207629
Synonyms:
US9265734, R01 | US9796664, Compound R01
Type:
Small organic molecule
Emp. Form.:
C20H25N3O2
Mol. Mass.:
339.4314
SMILES:
Cc1ccc(cc1)C(=O)NCCCCCC(=O)Nc1ccccc1N
Structure:
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