Reaction Details Report a problem with these data
Target
Histone deacetylase 1
Ligand
BDBM207631
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
18000±n/a nM
Citation
 Rusche, JR; Peet, NP; Hopper, A Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors US Patent  US9796664 Publication Date 10/24/2017 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM207631
Synonyms:
US9265734, R02 | US9796664, Compound R02
Type:
Small organic molecule
Emp. Form.:
C16H19FN4O2S
Mol. Mass.:
350.411
SMILES:
Nc1cc(F)ccc1NC(=O)CCCCCNC(=O)c1nccs1
Structure:
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