Reaction Details Report a problem with these data
Target
Histone deacetylase 3
Ligand
BDBM207631
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
2300±n/a nM
Citation
 Rusche, JR; Peet, NP; Hopper, A Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors US Patent  US9796664 Publication Date 10/24/2017 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM207631
Synonyms:
US9265734, R02 | US9796664, Compound R02
Type:
Small organic molecule
Emp. Form.:
C16H19FN4O2S
Mol. Mass.:
350.411
SMILES:
Nc1cc(F)ccc1NC(=O)CCCCCNC(=O)c1nccs1
Structure:
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