Reaction Details Report a problem with these data
Target
Histone deacetylase 3
Ligand
BDBM207634
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
1400±n/a nM
Citation
 Rusche, JR; Peet, NP; Hopper, A Compositions including 6-aminohexanoic acid derivatives as HDAC inhibitors US Patent  US9796664 Publication Date 10/24/2017 
Target
Name:
Histone deacetylase 3
Synonyms:
HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:
Enzyme
Mol. Mass.:
48829.55
Organism:
Homo sapiens (Human)
Description:
O15379
Residue:
428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCRFHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNNKICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEAFYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVINQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTVRNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQTIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDNDKESDVEI
  
Inhibitor
Name:
BDBM207634
Synonyms:
US9265734, R05 | US9796664, Compound R05
Type:
Small organic molecule
Emp. Form.:
C23H20FN3O2
Mol. Mass.:
389.4222
SMILES:
Cc1ccc(cc1)C(=O)Nc1cccc(\C=C\C(=O)Nc2ccc(F)cc2N)c1
Structure:
Search PDB for entries with ligand similarity: