Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM349268
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
240±n/a nM
Citation
 Rishton, G; Catalano, SM; Look, GC Isoindoline compositions and methods for treating neurodegenerative disease US Patent  US9796672 Publication Date 10/24/2017 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM349268
Synonyms:
US10207991, Ex. Cpd. No. 3 | US10611728, Example Compound 3 | US11691947, Example 3
Type:
Small organic molecule
Emp. Form.:
C19H21Cl2NO2
Mol. Mass.:
366.282
SMILES:
COc1cc(CC[C@@H](C)N2Cc3cc(Cl)c(Cl)cc3C2)ccc1O |r|
Structure:
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