Reaction Details Report a problem with these data
Target
Sigma non-opioid intracellular receptor 1
Ligand
BDBM349518
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
7.50±n/a nM
Citation
 Rishton, G; Catalano, SM; Look, GC Isoindoline compositions and methods for treating neurodegenerative disease US Patent  US9796672 Publication Date 10/24/2017 
Target
Name:
Sigma non-opioid intracellular receptor 1
Synonyms:
Aging-associated gene 8 protein | OPRS1 | SGMR1_HUMAN | SIG-1R | SIGMAR1 | SR-BP | SR31747-binding protein | SRBP | Sigma 1-type opioid receptor | Sigma opioid receptor | Sigma1R | hSigmaR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
25124.85
Organism:
Homo sapiens (Human)
Description:
Q99720
Residue:
223
Sequence:
MQWAVGRRWAWAALLLAVAAVLTQVVWLWLGTQSFVFQREEIAQLARQYAGLDHELAFSRLIVELRRLHPGHVLPDEELQWVFVNAGGWMGAMCLLHASLSEYVLLFGTALGSRGHSGRYWAEISDTIISGTFHQWREGTTKSEVFYPGETVVHGPGEATAVEWGPNTWMVEYGRGVIPSTLAFALADTVFSTQDFLTLFYTLRSYARGLRLELTTYLFGQDP
  
Inhibitor
Name:
BDBM349518
Synonyms:
US10207991, Ex. Cpd. No. 34 | US10611728, Example Compound 34 | US11691947, Example 34
Type:
Small organic molecule
Emp. Form.:
C21H26FNO2
Mol. Mass.:
343.435
SMILES:
COc1cc2CN(Cc2cc1OC)C(C)(C)CCc1ccc(F)cc1
Structure:
Search PDB for entries with ligand similarity: