Reaction Details Report a problem with these data
Target
Sigma intracellular receptor 2
Ligand
BDBM349546
Substrate
n/a
Meas. Tech.
Radioligand Binding Assay
Ki
6.90±n/a nM
Citation
 Rishton, G; Catalano, SM; Look, GC Isoindoline compositions and methods for treating neurodegenerative disease US Patent  US9796672 Publication Date 10/24/2017 
Target
Name:
Sigma intracellular receptor 2
Synonyms:
MAC30 | Meningioma-associated protein 30 | S2R | SGMR2_HUMAN | Sigma-2 receptor | Sigma2 receptor | TMEM97 | Transmembrane protein 97
Type:
Protein
Mol. Mass.:
20857.20
Organism:
Homo sapiens (Human)
Description:
Q5BJF2
Residue:
176
Sequence:
MGAPATRRCVEWLLGLYFLSHIPITLFMDLQAVLPRELYPVEFRNLLKWYAKEFKDPLLQEPPAWFKSFLFCELVFQLPFFPIATYAFLKGSCKWIRTPAIIYSVHTMTTLIPILSTFLFEDFSKASGFKGQRPETLHERLTLVSVYAPYLLIPFILLIFMLRSPYYKYEEKRKKK
  
Inhibitor
Name:
BDBM349546
Synonyms:
US10207991, Ex. Cpd. No. 61 | US10611728, Example Compound 61 | US11691947, Example 61
Type:
Small organic molecule
Emp. Form.:
C21H24F3NO4S
Mol. Mass.:
443.48
SMILES:
CC(C)(CCc1ccc(O)c(OC(F)(F)F)c1)N1Cc2ccc(cc2C1)S(C)(=O)=O
Structure:
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