Target
RAC-beta serine/threonine-protein kinase
Ligand
BDBM16221
Substrate
AKTide-2T
Meas. Tech.
PKB In Vitro Enzyme Assay
pH
7.2±n/a
Temperature
295.15±n/a K
IC50
280±30 nM
Citation
 Saxty, GWoodhead, SJBerdini, VDavies, TGVerdonk, MLWyatt, PGBoyle, RGBarford, DDownham, RGarrett, MDCarr, RA Identification of Inhibitors of Protein Kinase B Using Fragment-Based Lead Discovery. J Med Chem 50:2293-2296 (2007) [PubMed]  Article 
Target
Name:
RAC-beta serine/threonine-protein kinase
Synonyms:
AKT2 | AKT2_HUMAN | PKB beta | Protein kinase Akt-2 | Protein kinase B (Akt 2) | Protein kinase B beta (AKT2) | Protein kinase B, beta | RAC-PK-beta | RAC-alpha serine/threonine-protein kinase (AKT2) | RAC-beta serine/threonine-protein kinase | RAC-beta serine/threonine-protein kinase (AKT2) | Serine/threonine-protein kinase AKT | Serine/threonine-protein kinase AKT2 | Serine/threonine-protein kinase Rac alpha/beta
Type:
Enzyme
Mol. Mass.:
55766.64
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
481
Sequence:
MNEVSVIKEGWLHKRGEYIKTWRPRYFLLKSDGSFIGYKERPEAPDQTLPPLNNFSVAECQLMKTERPRPNTFVIRCLQWTTVIERTFHVDSPDEREEWMRAIQMVANSLKQRAPGEDPMDYKCGSPSDSSTTEEMEVAVSKARAKVTMNDFDYLKLLGKGTFGKVILVREKATGRYYAMKILRKEVIIAKDEVAHTVTESRVLQNTRHPFLTALKYAFQTHDRLCFVMEYANGGELFFHLSRERVFTEERARFYGAEIVSALEYLHSRDVVYRDIKLENLMLDKDGHIKITDFGLCKEGISDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHERLFELILMEEIRFPRTLSPEAKSLLAGLLKKDPKQRLGGGPSDAKEVMEHRFFLSINWQDVVQKKLLPPFKPQVTSEVDTRYFDDEFTAQSITITPPDRYDSLGLLELDQRTHFPQFSYSASIRE
  
Inhibitor
Name:
BDBM16221
Synonyms:
(2S)-2-(4-chlorophenyl)-2-[4-(1H-pyrazol-4-yl)phenyl]ethanamine | 4-{4-[(1S)-1-(4-chlorophenyl)propyl]phenyl}-1H-pyrazole | pyrazole-based inhibitor 8b
Type:
Small organic molecule
Emp. Form.:
C17H16ClN3
Mol. Mass.:
297.782
SMILES:
NC[C@H](c1ccc(Cl)cc1)c1ccc(cc1)-c1cn[nH]c1 |r|
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
AKTide-2T
Synonyms:
AKT/PKB/Rac Protein Kinase Substrate
Type:
Peptide
Mol. Mass.:
1719.90
Organism:
n/a
Description:
n/a
Residue:
14
Sequence:
ARKRERTYSFGHHA