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Target
Mitogen-activated protein kinase 3
Ligand
BDBM351223
Substrate
n/a
Meas. Tech.
Omnia Assay
IC50
<100±n/a nM
Citation
 Haq, N; Niu, D; Petter, RC; Qiao, L; Singh, J; Zhu, Z ERK inhibitors and uses thereof US Patent  US9796700 Publication Date 10/24/2017 
Target
Name:
Mitogen-activated protein kinase 3
Synonyms:
ERK1 | ERK1/ERK2 | Extracellular signal-regulated kinase 1 | Extracellular signal-regulated kinase 1 (ERK1) | MAP kinase ERK1 | MAPK3 | MAPK3/MAPK7 | MK03_HUMAN | Mitogen-activated protein kinase | Mitogen-activated protein kinase 3 | PRKM3
Type:
Protein
Mol. Mass.:
43136.58
Organism:
Homo sapiens (Human)
Description:
curated by PDB 4QTB
Residue:
379
Sequence:
MAAAAAQGGGGGEPRRTEGVGPGVPGEVEMVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRASTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFAMELDDLPKERLKELIFQETARFQPGVLEAP
  
Inhibitor
Name:
BDBM351223
Synonyms:
US9796700, Compound I-334
Type:
Small organic molecule
Emp. Form.:
C26H29F3N8O3
Mol. Mass.:
558.5555
SMILES:
COc1ccc(Nc2nc(Nc3cc(OC)nc(c3)N3CCN(C)CC3)ncc2C(F)(F)F)c(NC(=O)C=C)c1
Structure:
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