Target
Mitogen-activated protein kinase 14
Ligand
BDBM16394
Substrate
biotinylated GST-ATF2
Meas. Tech.
Enzyme Inhibition Assay
IC50
25±n/a nM
Citation
 McClure, KFLetavic, MAKalgutkar, ASGabel, CAAudoly, LBarberia, JTBraganza, JFCarter, DCarty, TJCortina, SRDombroski, MADonahue, KMElliott, NCGibbons, CPJordan, CKKuperman, AVLabasi, JMLaliberte, REMcCoy, JMNaiman, BMNelson, KLNguyen, HTPeese, KMSweeney, FJTaylor, TJTrebino, CEAbramov, YALaird, ERVolberg, WAZhou, JBach, JLombardo, F Structure-activity relationships of triazolopyridine oxazole p38 inhibitors: identification of candidates for clinical development. Bioorg Med Chem Lett 16:4339-44 (2006) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 14
Synonyms:
CSAID-binding protein | CSBP | CSBP1 | CSBP2 | CSPB1 | Cytokine suppressive anti-inflammatory drug-binding protein | MAP kinase 14 | MAP kinase MXI2 | MAP kinase p38 alpha | MAPK 14 | MAPK14 | MAX-interacting protein 2 | MK14_HUMAN | MXI2 | Mitogen-activated protein kinase p38 alpha | SAPK2A | Stress-activated protein kinase 2a | p38 MAP kinase alpha/beta
Type:
Serine/threonine-protein kinase
Mol. Mass.:
41286.76
Organism:
Homo sapiens (Human)
Description:
Q16539
Residue:
360
Sequence:
MSQERPTFYRQELNKTIWEVPERYQNLSPVGSGAYGSVCAAFDTKTGLRVAVKKLSRPFQSIIHAKRTYRELRLLKHMKHENVIGLLDVFTPARSLEEFNDVYLVTHLMGADLNNIVKCQKLTDDHVQFLIYQILRGLKYIHSADIIHRDLKPSNLAVNEDCELKILDFGLARHTDDEMTGYVATRWYRAPEIMLNWMHYNQTVDIWSVGCIMAELLTGRTLFPGTDHIDQLKLILRLVGTPGAELLKKISSESARNYIQSLTQMPKMNFANVFIGANPLAVDLLEKMLVLDSDKRITAAQALAHAYFAQYHDPDDEPVADPYDQSFESRDLLIDEWKSLTYDEVISFVPPPLDQEEMES
  
Inhibitor
Name:
BDBM16394
Synonyms:
2-{6-[4-(2,5-difluorophenyl)-1,3-oxazol-5-yl]-[1,2,4]triazolo[3,4-a]pyridin-3-yl}propan-2-ol | triazolopyridine oxazole inhibitor 65
Type:
Small organic molecule
Emp. Form.:
C18H14F2N4O2
Mol. Mass.:
356.3262
SMILES:
CC(C)(O)c1nnc2ccc(cn12)-c1ocnc1-c1cc(F)ccc1F
Structure:
Search PDB for entries with ligand similarity:
Substrate
Name:
biotinylated GST-ATF2
Synonyms:
ATF-2-GST | ATF2 | Activating transcription factor 2 | Activating transcription factor 2-GST fusion | GST-ATF2 | biotinylated ATF2 substrate | biotinylated activating transcription factor 2
Type:
Other Protein Type
Mol. Mass.:
12237.77
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
109
Sequence:
MSDDKPFLCTAPGCGQRFTNEDHLAVHKHKHEMTLKFGPARNDSVIVADQTPTPTRFLKNCEEVGLFNELASPFENEFKKASEDDIKKMPLDLSPLATPIIRSKIEEPS