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Target
SRSF protein kinase 1
Ligand
BDBM221073
Substrate
n/a
Meas. Tech.
In Vitro Kinase Assay
IC50
54.7±n/a nM
Citation
 Bates, D; Morris, J Piperazine derivatives for treating disorders US Patent  US9796707 Publication Date 10/24/2017 
Target
Name:
SRSF protein kinase 1
Synonyms:
SRPK1 | SRPK1_HUMAN | SRSF protein kinase 1 (SRPK1) | Serine/arginine-protein kinase 1 (SRPK1) | Serine/threonine-protein kinase SRPK1
Type:
Protein
Mol. Mass.:
74318.38
Organism:
Homo sapiens (Human)
Description:
Q96SB4
Residue:
655
Sequence:
MERKVLALQARKKRTKAKKDKAQRKSETQHRGSAPHSESDLPEQEEEILGSDDDEQEDPNDYCKGGYHLVKIGDLFNGRYHVIRKLGWGHFSTVWLSWDIQGKKFVAMKVVKSAEHYTETALDEIRLLKSVRNSDPNDPNREMVVQLLDDFKISGVNGTHICMVFEVLGHHLLKWIIKSNYQGLPLPCVKKIIQQVLQGLDYLHTKCRIIHTDIKPENILLSVNEQYIRRLAAEATEWQRSGAPPPSGSAVSTAPQPKPADKMSKNKKKKLKKKQKRQAELLEKRMQEIEEMEKESGPGQKRPNKQEESESPVERPLKENPPNKMTQEKLEESSTIGQDQTLMERDTEGGAAEINCNGVIEVINYTQNSNNETLRHKEDLHNANDCDVQNLNQESSFLSSQNGDSSTSQETDSCTPITSEVSDTMVCQSSSTVGQSFSEQHISQLQESIRAEIPCEDEQEQEHNGPLDNKGKSTAGNFLVNPLEPKNAEKLKVKIADLGNACWVHKHFTEDIQTRQYRSLEVLIGSGYNTPADIWSTACMAFELATGDYLFEPHSGEEYTRDEDHIALIIELLGKVPRKLIVAGKYSKEFFTKKGDLKHITKLKPWGLFEVLVEKYEWSQEEAAGFTDFLLPMLELIPEKRATAAECLRHPWLNS
  
Inhibitor
Name:
BDBM221073
Synonyms:
SPHINX scaffold, 3 | US9695160, SPHINX7 | US9796707, Reference Compound SPHINX7
Type:
Small organic molecule
Emp. Form.:
C25H28F3N5O2
Mol. Mass.:
487.5173
SMILES:
CN(C)CCN1CCN(CC1)c1ccc(cc1NC(=O)c1ccc(o1)-c1ccncc1)C(F)(F)F
Structure:
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