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TargetAldose reductase (AR)
LigandBDBM16436
Substrate/CompetitorBDBM16416
Meas. Tech.Enzyme Inhibition Assay
pH7±n/a
Temperature298.15±n/a K
Ki 950±130 nM
Citation Brownlee, JMCarlson, EMilne, ACPape, EHarrison, DH Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes. Bioorg Chem34:424-44 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Aldose reductase (AR)
Name:Aldose reductase
Synonyms:AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase
Type:Protein
Mol. Mass.:35855.50
Organism:Homo sapiens (Human)
Description:P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
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BDBM16436
NameBDBM16436
Synonyms:6,8-disulfanyloctanoic acid | D,L-Dihydrolipoic acid | Dihydrothioctic acid | dihydrolipoate
TypeSmall organic molecule
Emp. Form.C8H16O2S2
Mol. Mass.208.341
SMILESOC(=O)CCCCC(S)CCS
Structure
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BDBM16416
NameBDBM16416
Synonyms:pentane-1,2,3,4,5-pentol | xylitol
TypeSmall organic molecule
Emp. Form.C5H12O5
Mol. Mass.152.1458
SMILESOCC(O)C(O)C(O)CO
Structure
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