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TargetAldose reductase (AR)
LigandBDBM16437
Substrate/CompetitorBDBM16418
Meas. Tech.Enzyme Inhibition Assay
Ki 8100±n/a nM
Citation Brownlee, JMCarlson, EMilne, ACPape, EHarrison, DH Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes. Bioorg Chem34:424-44 (2006) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
Aldose reductase (AR)
Name:Aldose reductase
Synonyms:AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase
Type:Protein
Mol. Mass.:35855.50
Organism:Homo sapiens (Human)
Description:P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQ
EKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGK
EFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKP
AVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAK
HNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCA
LLSCTSHKDYPFHEEF
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BDBM16437
NameBDBM16437
Synonyms:2-{3-[(2-hydroxyethyl)sulfanyl]-2,5-dioxopyrrolidin-1-yl}acetic acid | beta-Mercaptoethanol , N-glycylthiosuccinimide
Typeadduct
Emp. Form.C8H11NO5S
Mol. Mass.233.242
SMILESOCCSC1CC(=O)N(CC(O)=O)C1=O
Structure
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BDBM16418
NameBDBM16418
Synonyms:benzyl alcohol | phenylmethanol
TypeSmall organic molecule
Emp. Form.C7H8O
Mol. Mass.108.1378
SMILESOCc1ccccc1
Structure
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