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Target
Aldo-keto reductase family 1 member B1
Ligand
BDBM16312
Substrate
BDBM16443
Meas. Tech.
In Vitro Aldose Reductase Inhibition Assay
pH
7±n/a
Temperature
297.15±n/a K
IC50
140±n/a nM
Citation
 Mylari, BL; Armento, SJ; Beebe, DA; Conn, EL; Coutcher, JB; Dina, MS; O'Gorman, MT; Linhares, MC; Martin, WH; Oates, PJ; Tess, DA; Withbroe, GJ; Zembrowski, WJ A highly selective, non-hydantoin, non-carboxylic acid inhibitor of aldose reductase with potent oral activity in diabetic rat models: 6-(5-chloro-3-methylbenzofuran- 2-sulfonyl)-2-H-pyridazin-3-one. J Med Chem 46:2283-6 (2003) [PubMed]  Article 
Target
Name:
Aldo-keto reductase family 1 member B1
Synonyms:
AKR1B1 | ALDR1 | ALDR_HUMAN | ALR2 | AR | Aldo-keto reductase family 1 member B1 (AKR1B1) | Aldose Reductase (ALR2) | Aldose reductase | Aldose reductase (AR)
Type:
Protein
Mol. Mass.:
35855.50
Organism:
Homo sapiens (Human)
Description:
P15121. 4LAU; 2IKI; 4LB4; 2FZD; 2FZ8; 1US0
Residue:
316
Sequence:
MASRLLLNNGAKMPILGLGTWKSPPGQVTEAVKVAIDVGYRHIDCAHVYQNENEVGVAIQEKLREQVVKREELFIVSKLWCTYHEKGLVKGACQKTLSDLKLDYLDLYLIHWPTGFKPGKEFFPLDESGNVVPSDTNILDTWAAMEELVDEGLVKAIGISNFNHLQVEMILNKPGLKYKPAVNQIECHPYLTQEKLIQYCQSKGIVVTAYSPLGSPDRPWAKPEDPSLLEDPRIKAIAAKHNKTTAQVLIRFPMQRNLVVIPKSVTPERIAENFKVFDFELSSQDMTTLLSYNRNWRVCALLSCTSHKDYPFHEEF
  
Inhibitor
Name:
BDBM16312
Synonyms:
(4S)-6-fluoro-2,3-dihydrospiro[1-benzopyran-4,4'-imidazolidine]-2',5'-dione | CHEMBL266497 | Sorbinil
Type:
Small organic molecule
Emp. Form.:
C11H9FN2O3
Mol. Mass.:
236.1992
SMILES:
Fc1ccc2OCC[C@]3(NC(=O)NC3=O)c2c1 |r|
Structure:
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Substrate
Name:
BDBM16443
Synonyms:
(2R)-2,3-dihydroxypropanal | D-glyceraldehyde | Triose
Type:
Small organic molecule
Emp. Form.:
C3H6O3
Mol. Mass.:
90.0779
SMILES:
OC[C@@H](O)C=O
Structure:
Search PDB for entries with ligand similarity: