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TargetcAMP-Dependent Protein Kinase (PKA)
LigandBDBM16547
Substrate/Competitorbiotinylated kemptide
Meas. Tech.PKA/PKC Kinase Assay
IC50 15±n/a nM
Citation Zhu, GDGandhi, VBGong, JThomas, SWoods, KWSong, XLi, TDiebold, RBLuo, YLiu, XGuan, RKlinghofer, VJohnson, EFBouska, JOlson, AMarsh, KCStoll, VSMamo, MPolakowski, JCampbell, TJMartin, RLGintant, GAPenning, TDLi, QRosenberg, SHGiranda, VL Syntheses of potent, selective, and orally bioavailable indazole-pyridine series of protein kinase b/akt inhibitors with reduced hypotension. J Med Chem50:2990-3003 (2007) [PubMed]  Article
More Info.:Get all data from this article,   Solution Info,  Assay Method
 
cAMP-Dependent Protein Kinase (PKA)
Name:cAMP-dependent protein kinase A
Synonyms:PKA C-alpha | PKC | Protein Kinase C | Protein Kinase C, bovine brain | cAMP-dependent Protein Kinase, bovine heart | cAMP-dependent protein kinase A | cAMP-dependent protein kinase alpha-catalytic subunit | cAMP-dependent protein kinase, alpha-catalytic subunit
Type:Enzyme Complex
Mol. Mass.:40627.77
Organism:Bos taurus (bovine)
Description:The PKA holoenzyme purified from bovine heart, exists as an inactive tetrameric complex, which consists of a regulatory dimer associated with two catalytic subunits. It requires cAMP to activate the enzymatic reaction.
Residue:351
Sequence:
MGNAAAAKKGSEQESVKEFLAKAKEDFLKKWENPAQNTAHLDQFERIKTLGTGSFGRVML
VKHMETGNHYAMKILDKQKVVKLKQIEHTLNEKRILQAVNFPFLVKLEFSFKDNSNLYMV
MEYVPGGEMFSHLRRIGRFSEPHARFYAAQIVLTFEYLHSLDLIYRDLKPENLLIDQQGY
IQVTDFGFAKRVKGRTWTLCGTPEYLAPEIILSKGYNKAVDWWALGVLIYEMAAGYPPFF
ADQPIQIYEKIVSGKVRFPSHFSSDLKDLLRNLLQVDLTKRFGNLKNGVNDIKNHKWFAT
TDWIAIYQRKVEAPFIPKFKGPGDTSNFDDYEEEEIRVSINEKCGKEFSEF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM16547
NameBDBM16547
Synonyms:(2S)-1-(4-bromophenyl)-3-{[5-(3-methyl-1H-indazol-5-yl)pyridin-3-yl]oxy}propan-2-amine | 5-{5-[(2S)-2-amino-3-(4-bromophenyl)propoxy]pyridin-3-yl}-3-methyl-1H-indazole | indazole-pyridine, 13l
TypeSmall organic molecule
Emp. Form.C22H21BrN4O
Mol. Mass.437.332
SMILESCc1n[nH]c2ccc(cc12)-c1cncc(OC[C@@H](N)Cc2ccc(Br)cc2)c1 |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
biotinylated kemptide
Name:biotinylated kemptide
Synonyms:n/a
Type:Biotinylated Peptide
Mol. Mass.:1353.09
Organism:n/a
Description:n/a
Residue:12
Sequence:
biotin-hx-LRRASLG