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Target
Tyrosine-protein kinase JAK2 [808-1132]
Ligand
BDBM127854
Substrate
n/a
Meas. Tech.
Jak2 Inhibition Assay
IC50
446±n/a nM
Citation
 Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent  US9796724 Publication Date 10/24/2017 
Target
Name:
Tyrosine-protein kinase JAK2 [808-1132]
Synonyms:
JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132)
Type:
Protein
Mol. Mass.:
39171.39
Organism:
Homo sapiens (Human)
Description:
O60674[808-1132]
Residue:
335
Sequence:
FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM127854
Synonyms:
US10251889, Example 227 | US10758542, Example 227 | US8791123, 227 | US9782415, Example 227 | US9796724, Example 227
Type:
Small organic molecule
Emp. Form.:
C20H23FN6O2
Mol. Mass.:
398.434
SMILES:
CC(C)NC(=O)c1cnn2ccc(nc12)N1CCC[C@@H]1c1cc(F)cn(C)c1=O |r|
Structure:
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