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Target
Tyrosine-protein kinase JAK2 [808-1132]
Ligand
BDBM127865
Substrate
n/a
Meas. Tech.
Jak2 Inhibition Assay
IC50
499±n/a nM
Citation
 Allen, S; Andrews, SW; Condroski, KR; Haas, J; Huang, L; Jiang, Y; Kercher, T; Seo, J Substituted pyrazolo[1,5-a]pyrimidine compounds as Trk kinase inhibitors US Patent  US9796724 Publication Date 10/24/2017 
Target
Name:
Tyrosine-protein kinase JAK2 [808-1132]
Synonyms:
JAK2 | JAK2 (aa 808-1132) | JAK2_HUMAN | Tyrosine-protein kinase JAK2 JH1 (808-1132)
Type:
Protein
Mol. Mass.:
39171.39
Organism:
Homo sapiens (Human)
Description:
O60674[808-1132]
Residue:
335
Sequence:
FRAIIRDLNSLFTPDYELLTENDMLPNMRIGALGFSGAFEDRDPTQFEERHLKFLQQLGKGNFGSVEMCRYDPLQDNTGEVVAVKKLQHSTEEHLRDFEREIEILKSLQHDNIVKYKGVCYSAGRRNLKLIMEYLPYGSLRDYLQKHKERIDHIKLLQYTSQICKGMEYLGTKRYIHRDLATRNILVENENRVKIGDFGLTKVLPQDKEYYKVKEPGESPIFWYAPESLTESKFSVASDVWSFGVVLYELFTYIEKSKSPPAEFMRMIGNDKQGQMIVFHLIELLKNNGRLPRPDGCPDEIYMIMTECWNNNVNQRPSFRDLALRVDQIRDNMAG
  
Inhibitor
Name:
BDBM127865
Synonyms:
US10251889, Example 238 | US10758542, Example 238 | US8791123, 238 | US9782415, Example 238 | US9796724, Example 238
Type:
Small organic molecule
Emp. Form.:
C23H27FN6O3
Mol. Mass.:
454.4973
SMILES:
Cn1cc(F)cc([C@H]2CCCN2c2ccn3ncc(C(=O)NC4CC[C@H](O)CC4)c3n2)c1=O |r,wD:7.6,25.26,(-7.44,5.2,;-5.95,4.81,;-4.86,5.9,;-3.37,5.5,;-2.28,6.59,;-2.97,4.01,;-4.06,2.92,;-3.66,1.43,;-4.57,.19,;-3.66,-1.06,;-2.2,-.58,;-2.2,.96,;-.87,1.73,;-.87,3.27,;.47,4.04,;1.8,3.27,;3.27,3.74,;4.17,2.5,;3.27,1.25,;3.66,-.24,;2.58,-1.33,;5.15,-.64,;5.55,-2.12,;7.04,-2.52,;7.44,-4.01,;6.35,-5.1,;6.75,-6.59,;4.86,-4.7,;4.46,-3.21,;1.8,1.73,;.47,.96,;-5.55,3.32,;-6.64,2.23,)|
Structure:
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