Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM354154
Substrate
n/a
Meas. Tech.
Factor D Assay
IC50
>10000±n/a nM
Citation
 Gadhachanda, VR; Wang, Q; Pais, G; Hashimoto, A; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Wiles, JA; Phadke, AS Aryl, heteroaryl, and heterocyclic compounds for treatment of complement mediated disorders US Patent  US9796741 Publication Date 10/24/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM354154
Synonyms:
1-(2-((2S,4R)-4-fluoro- 2-(4-(6- methylimidazo[2,1- b]thiazol-5-yl)thiazol-2- ylcarbamoyl)pyrrolidin- 1-yl)-2-oxoethyl)-5- (pyridazin-4-yl)-1H- indazole-3-carboxamide | US9796741, cmp No. 58
Type:
Small organic molecule
Emp. Form.:
C29H24FN9O3S2
Mol. Mass.:
629.688
SMILES:
Cc1nc2sccn2c1-c1csc(NC(=O)[C@@H]2C[C@@H](F)CN2C(=O)CC2N=C(C(N)=O)c3cc(ccc23)-c2ccnnc2)n1 |r,t:29|
Structure:
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