Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM354194
Substrate
n/a
Meas. Tech.
Factor D Assay
IC50
>10000±n/a nM
Citation
 Gadhachanda, VR; Wang, Q; Pais, G; Hashimoto, A; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Wiles, JA; Phadke, AS Aryl, heteroaryl, and heterocyclic compounds for treatment of complement mediated disorders US Patent  US9796741 Publication Date 10/24/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM354194
Synonyms:
(2S,4R)-1-(2-(3-acetyl- 5-(pyridazin-4-yl)-1H- indol-1-yl)acetyl)-4- fluoro-N-(5-methyl-2- (trifluoromethyl)- [1,2,4]triazolo[1,5- a]pyrimidin-7- yl)pyrrolidine-2- carboxamide | US10287301, Compound 97 | US10822352, Comp No. 97 | US9796741, cmp No. 97
Type:
Small organic molecule
Emp. Form.:
C28H23F4N9O3
Mol. Mass.:
609.5343
SMILES:
CC(=O)c1cn(CC(=O)N2C[C@H](F)C[C@H]2C(=O)Nc2cc(C)nc3nc(nn23)C(F)(F)F)c2ccc(cc12)-c1ccnnc1 |r|
Structure:
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