Reaction Details Report a problem with these data
Target
Complement factor D
Ligand
BDBM354256
Substrate
n/a
Meas. Tech.
Factor D Assay
IC50
>10000±n/a nM
Citation
 Gadhachanda, VR; Wang, Q; Pais, G; Hashimoto, A; Chen, D; Wang, X; Agarwal, A; Deshpande, M; Wiles, JA; Phadke, AS Aryl, heteroaryl, and heterocyclic compounds for treatment of complement mediated disorders US Patent  US9796741 Publication Date 10/24/2017 
Target
Name:
Complement factor D
Synonyms:
Adipsin | C3 convertase activator | CFAD_HUMAN | CFD | DF | PFD | Properdin factor D
Type:
Protein
Mol. Mass.:
27039.19
Organism:
Homo sapiens (Human)
Description:
P00746
Residue:
253
Sequence:
MHSWERLAVLVLLGAAACAAPPRGRILGGREAEAHARPYMASVQLNGAHLCGGVLVAEQWVLSAAHCLEDAADGKVQVLLGAHSLSQPEPSKRLYDVLRAVPHPDSQPDTIDHDLLLLQLSEKATLGPAVRPLPWQRVDRDVAPGTLCDVAGWGIVNHAGRRPDSLQHVLLPVLDRATCNRRTHHDGAITERLMCAESNRRDSCKGDSGGPLVCGGVLEGVVTSGSRVCGNRKKPGIYTRVASYAAWIDSVLA
  
Inhibitor
Name:
BDBM354256
Synonyms:
(2S,4R)-1-(2-(3-acetyl- 5-(pyridazin-4-yl)-1H- indol-1-yl)acetyl)-4- fluoro-N-(2-methyl-3- oxo-3,4-dihydro-2H- benzo[b][1,4]oxazin-5- yl)pyrrolidine-2- carboxamide | US10287301, Compound 153 | US10822352, Comp No. 153 | US9796741, cmp No. 153
Type:
Small organic molecule
Emp. Form.:
C30H27FN6O5
Mol. Mass.:
570.571
SMILES:
CC1Oc2cccc(NC(=O)[C@@H]3C[C@@H](F)CN3C(=O)Cn3cc(C(C)=O)c4cc(ccc34)-c3ccnnc3)c2NC1=O |r|
Structure:
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