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Target
Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48
Ligand
BDBM352016
Substrate
n/a
Meas. Tech.
Inhibition Assay
IC50
6800±n/a nM
Citation
 Maloney, DJ; Rosenthal, AS; Jadhav, A; Dexheimer, TS; Simeonov, A; Zhuang, Z; Liang, Q; Luci, DK Inhibitors of the USP1/UAF1 deubiquitinase complex and uses thereof US Patent  US9802904 Publication Date 10/31/2017 
Target
Name:
Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48
Synonyms:
USP1/UAF1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48
Type:
Protein
Mol. Mass.:
n/a
Description:
n/a
Components:
This complex has 2 components.
Component 1
Name:
WD repeat-containing protein 48
Synonyms:
KIAA1449 | UAF1 | USP1-associated factor 1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 | WD repeat endosomal protein | WD repeat-containing protein 48 | WDR48 | WDR48_HUMAN | p80
Type:
PROTEIN
Mol. Mass.:
76215.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_109642
Residue:
677
Sequence:
MAAHHRQNTAGRRKVQVSYVIRDEVEKYNRNGVNALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDIVLCCNGKTLISASSDTTVKVWNAHKGFCMSTLRTHKDYVKALAYAKDKELVASAGLDRQIFLWDVNTLTALTASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGSTEKVLRVWDPRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLWSLGQQRCIATYRVHDEGVWALQVNDAFTHVYSGGRDRKIYCTDLRNPDIRVLICEEKAPVLKMELDRSADPPPAIWVATTKSTVNKWTLKGIHNFRASGDYDNDCTNPITPLCTQPDQVIKGGASIIQCHILNDKRHILTKDTNNNVAYWDVLKACKVEDLGKVDFEDEIKKRFKMVYVPNWFSVDLKTGMLTITLDESDCFAAWVSAKDAGFSSPDGSDPKLNLGGLLLQALLEYWPRTHVNPMDEEENEVNHVNGEQENRVQKGNGYFQVPPHTPVIFGEAGGRTLFRLLCRDSGGETESMLLNETVPQWVIDITVDKNMPKFNKIPFYLQPHASSGAKTLKKDRLSASDMLQVRKVMEHVYEKIINLDNESQTTSSSNNEKPGEQEKEEDIAVLAEEKIELLCQDQVLDPNMDLRTVKHFIWKSGGDLTLHYRQKST
  
Component 2
Name:
Ubiquitin carboxyl-terminal hydrolase 1
Synonyms:
Deubiquitinating enzyme 1 | UBP1_HUMAN | USP1 | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48  | Ubiquitin thioesterase 1 | Ubiquitin-specific-processing protease 1 | hUBP
Type:
PROTEIN
Mol. Mass.:
88191.62
Organism:
Homo sapiens (Human)
Description:
ChEMBL_104169
Residue:
785
Sequence:
MPGVIPSESNGLSRGSPSKKNRLSLKFFQKKETKRALDFTDSQENEEKASEYRASEIDQVVPAAQSSPINCEKRENLLPFVGLNNLGNTCYLNSILQVLYFCPGFKSGVKHLFNIISRKKEALKDEANQKDKGNCKEDSLASYELICSLQSLIISVEQLQASFLLNPEKYTDELATQPRRLLNTLRELNPMYEGYLQHDAQEVLQCILGNIQETCQLLKKEEVKNVAELPTKVEEIPHPKEEMNGINSIEMDSMRHSEDFKEKLPKGNGKRKSDTEFGNMKKKVKLSKEHQSLEENQRQTRSKRKATSDTLESPPKIIPKYISENESPRPSQKKSRVKINWLKSATKQPSILSKFCSLGKITTNQGVKGQSKENECDPEEDLGKCESDNTTNGCGLESPGNTVTPVNVNEVKPINKGEEQIGFELVEKLFQGQLVLRTRCLECESLTERREDFQDISVPVQEDELSKVEESSEISPEPKTEMKTLRWAISQFASVERIVGEDKYFCENCHHYTEAERSLLFDKMPEVITIHLKCFAASGLEFDCYGGGLSKINTPLLTPLKLSLEEWSTKPTNDSYGLFAVVMHSGITISSGHYTASVKVTDLNSLELDKGNFVVDQMCEIGKPEPLNEEEARGVVENYNDEEVSIRVGGNTQPSKVLNKKNVEAIGLLGGQKSKADYELYNKASNPDKVASTAFAENRNSETSDTTGTHESDRNKESSDQTGINISGFENKISYVVQSLKEYEGKWLLFDDSEVKVTEEKDFLNSLSPSTSPTSTPYLLFYKKL
  
Inhibitor
Name:
BDBM352016
Synonyms:
US9802904, 77
Type:
Small organic molecule
Emp. Form.:
C24H28N4
Mol. Mass.:
372.5059
SMILES:
CC(C)c1ccccc1-c1ncc(C)c(NCC2CC(C2)c2cccnc2)n1 |(-.75,-5.7,;.58,-6.47,;.58,-8.01,;1.92,-5.7,;3.25,-6.48,;4.58,-5.71,;4.58,-4.17,;3.25,-3.4,;1.92,-4.17,;.58,-3.4,;-.75,-4.17,;-2.08,-3.4,;-2.08,-1.85,;-3.42,-1.08,;-.75,-1.08,;-.75,.46,;.39,1.49,;1.86,1.01,;2.49,-.4,;4.23,.24,;3.32,1.49,;5.7,-.21,;6.85,.82,;8.31,.34,;8.63,-1.16,;7.49,-2.19,;6.02,-1.72,;.58,-1.85,)|
Structure:
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