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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM352026
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y; Zhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent  US9802918 Publication Date 10/31/2017 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM352026
Synonyms:
(3R,4R,5S)-3-Amino-1-(3-(((6-(2,6-difluoro-4-(1-hydroxycyclobutyl)phenyl)-5-fluoropyridin-2-yl)methyl)amino)pyridin-4-yl)-5-methylpiperidin-4-ol | US9802918, Example 2
Type:
Small organic molecule
Emp. Form.:
C27H30F3N5O2
Mol. Mass.:
513.5546
SMILES:
C[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1 |r,wU:5.5,1.0,wD:7.8,(-.67,.98,;-2,.21,;-2,-1.33,;-3.33,-2.1,;-4.67,-1.33,;-4.67,.21,;-6,.98,;-3.33,.98,;-3.33,2.52,;-3.33,-3.64,;-4.67,-4.41,;-4.67,-5.95,;-3.33,-6.72,;-2,-5.95,;-2,-4.41,;-.67,-3.64,;.67,-4.41,;2,-3.64,;3.33,-4.41,;4.67,-3.64,;4.67,-2.1,;6,-1.33,;3.33,-1.33,;2,-2.1,;3.33,.21,;2,.98,;.67,.21,;2,2.52,;3.33,3.29,;4.67,2.52,;4.67,.98,;6,.21,;3.33,4.83,;4.67,4.06,;3.73,6.32,;2.25,6.72,;1.85,5.23,)|
Structure:
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