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TargetSerine/threonine-protein kinase pim-1
LigandBDBM352030
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50<10±n/a nM
Citation Vechorkin, OLi, YZhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent US9802918 Publication Date 10/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pim-1
Name:Serine/threonine-protein kinase pim-1
Synonyms:PIM-1 Kinase | PIM1 | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:Protein
Mol. Mass.:35681.82
Organism:Homo sapiens (Human)
Description:P11309
Residue:313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM352030
NameBDBM352030
Synonyms:(3R,4R,5S)-3-Amino-1-(3-(((6-(2,6-difluoro-4-(4-hydroxytetrahydro-2H-pyran-4-yl)phenyl)-5-fluoropyridin-2-yl)methyl)amino)pyridin-4-yl)-5-methylpiperidin-4-ol | US9802918, Example 3
TypeSmall organic molecule
Emp. Form.C28H32F3N5O3
Mol. Mass.543.5806
SMILESC[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOCC1 |r,wU:5.5,1.0,wD:7.8,(-.67,.59,;-2,-.18,;-2,-1.72,;-3.33,-2.49,;-4.67,-1.72,;-4.67,-.18,;-6,.59,;-3.33,.59,;-3.33,2.13,;-3.33,-4.03,;-4.67,-4.8,;-4.67,-6.34,;-3.33,-7.11,;-2,-6.34,;-2,-4.8,;-.67,-4.03,;.67,-4.8,;2,-4.03,;3.33,-4.8,;4.67,-4.03,;4.67,-2.49,;6,-1.72,;3.33,-1.72,;2,-2.49,;3.33,-.18,;2,.59,;.67,-.18,;2,2.13,;3.33,2.9,;4.67,2.13,;4.67,.59,;6,-.18,;3.33,4.44,;4.67,3.67,;4.1,5.78,;3.33,7.11,;1.79,7.11,;1.02,5.78,;1.79,4.44,)|
Structure
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