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TargetSerine/threonine-protein kinase PIM
LigandBDBM352031
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50<10±n/a nM
Citation Vechorkin, OLi, YZhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent US9802918 Publication Date 10/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase PIM
Name:Serine/threonine-protein kinase PIM
Synonyms:2.7.11.1 | PIM-1 Kinase | PIM1 | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:Protein
Mol. Mass.:45417.87
Organism:Homo sapiens (Human)
Description:P11309
Residue:313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
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  Blast E-value cutoff:
BDBM352031
NameBDBM352031
Synonyms:3-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl}amino)methyl]-3-fluoropyridin-2-yl}-3,5-difluorophenyl)tetrahydrofuran-3-ol | US9802918, Example 4
TypeSmall organic molecule
Emp. Form.C27H30F3N5O2
Mol. Mass.513.5546
SMILESC[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOC1 |r,wU:3.3,1.0,(-.67,.74,;-2,-.03,;-3.33,.74,;-4.67,-.03,;-6,.74,;-4.67,-1.57,;-3.33,-2.34,;-2,-1.57,;-3.33,-3.88,;-4.67,-4.65,;-4.67,-6.19,;-3.33,-6.96,;-2,-6.19,;-2,-4.65,;-.67,-3.88,;.67,-4.65,;2,-3.88,;3.33,-4.65,;4.67,-3.88,;4.67,-2.34,;6,-1.57,;3.33,-1.57,;2,-2.34,;3.33,-.03,;2,.74,;.67,-.03,;2,2.28,;3.33,3.05,;4.67,2.28,;4.67,.74,;6,-.03,;3.33,4.59,;4.67,3.82,;2.09,5.5,;2.56,6.96,;4.1,6.96,;4.58,5.5,)|
Structure
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