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TargetSerine/threonine-protein kinase pim-3
LigandBDBM352033
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50<10±n/a nM
Citation Vechorkin, OLi, YZhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent US9802918 Publication Date 10/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pim-3
Name:Serine/threonine-protein kinase pim-3
Synonyms:Serine/threonine-protein kinase pim-3 (PIM3)
Type:Protein
Mol. Mass.:35888.19
Organism:Homo sapiens (Human)
Description:Q86V86
Residue:326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
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  Blast E-value cutoff:
BDBM352033
NameBDBM352033
Synonyms:1-(4-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyridin-3-ylamino)methyl)-3-fluoropyridin-2-yl)-3,5-difluorophenyl)cyclobutanol | US9802918, Example 5
TypeSmall organic molecule
Emp. Form.C27H30F3N5O
Mol. Mass.497.5552
SMILESC[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1 |r,wU:1.0,3.3,(-.67,.98,;-2,.21,;-3.33,.98,;-4.67,.21,;-6,.98,;-4.67,-1.33,;-3.33,-2.1,;-2,-1.33,;-3.33,-3.64,;-4.67,-4.41,;-4.67,-5.95,;-3.33,-6.72,;-2,-5.95,;-2,-4.41,;-.67,-3.64,;.67,-4.41,;2,-3.64,;3.33,-4.41,;4.67,-3.64,;4.67,-2.1,;6,-1.33,;3.33,-1.33,;2,-2.1,;3.33,.21,;2,.98,;.67,.21,;2,2.52,;3.33,3.29,;4.67,2.52,;4.67,.98,;6,.21,;3.33,4.83,;4.67,4.06,;3.73,6.32,;2.25,6.72,;1.85,5.23,)|
Structure
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