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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM352034
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y; Zhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent  US9802918 Publication Date 10/31/2017 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM352034
Synonyms:
4-(4-(6-((4-((3S,5R)-3-Amino-5-methylpiperidin-1-yl)pyridin-3-ylamino)methyl)-3-fluoropyridin-2-yl)-3,5-difluorophenyl)tetrahydro-2H-pyran-4-ol | US9802918, Example 6
Type:
Small organic molecule
Emp. Form.:
C28H32F3N5O2
Mol. Mass.:
527.5812
SMILES:
C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCOCC1 |r,wU:1.0,3.3,(-.67,.59,;-2,-.18,;-3.33,.59,;-4.67,-.18,;-6,.59,;-4.67,-1.72,;-3.33,-2.49,;-2,-1.72,;-3.33,-4.03,;-4.67,-4.8,;-4.67,-6.34,;-3.33,-7.11,;-2,-6.34,;-2,-4.8,;-.67,-4.03,;.67,-4.8,;2,-4.03,;3.33,-4.8,;4.67,-4.03,;4.67,-2.49,;6,-1.72,;3.33,-1.72,;2,-2.49,;3.33,-.18,;2,.59,;.67,-.18,;2,2.13,;3.33,2.9,;4.67,2.13,;4.67,.59,;6,-.18,;3.33,4.44,;4.67,3.67,;4.1,5.78,;3.33,7.11,;1.79,7.11,;1.02,5.78,;1.79,4.44,)|
Structure:
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