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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM352075
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<100±n/a nM
Citation
 Vechorkin, O; Li, Y; Zhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent  US9802918 Publication Date 10/31/2017 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM352075
Synonyms:
1-(4-{6-[({4-[(3S,5R)-3-Amino-5-(trifluoromethyl)piperidin-1-yl]pyridin-3-yl}amino)methyl]-3-fluoropyridin-2-yl}-3,5-difluorophenyl)cyclobutanol | US9802918, Example 7
Type:
Small organic molecule
Emp. Form.:
C27H27F6N5O
Mol. Mass.:
551.5266
SMILES:
N[C@H]1C[C@H](CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C1(O)CCC1)C(F)(F)F |r,wU:1.0,3.39,(-6,.84,;-4.67,.07,;-3.33,.84,;-1.95,.09,;-2,-1.47,;-3.33,-2.24,;-4.67,-1.47,;-3.33,-3.78,;-4.67,-4.55,;-4.67,-6.09,;-3.33,-6.86,;-2,-6.09,;-2,-4.55,;-.67,-3.78,;.67,-4.55,;2,-3.78,;3.33,-4.55,;4.67,-3.78,;4.67,-2.24,;6,-1.47,;3.33,-1.47,;2,-2.24,;3.33,.07,;2,.84,;.67,.07,;2,2.38,;3.33,3.15,;4.67,2.38,;4.67,.84,;6,.07,;3.33,4.69,;4.67,3.92,;4.42,5.78,;3.33,6.86,;2.25,5.78,;-.62,.86,;.71,1.63,;.15,-.47,;-1.39,2.2,)|
Structure:
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