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TargetSerine/threonine-protein kinase pim-3
LigandBDBM352083
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50<10±n/a nM
Citation Vechorkin, OLi, YZhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent US9802918 Publication Date 10/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pim-3
Name:Serine/threonine-protein kinase pim-3
Synonyms:Serine/threonine-protein kinase pim-3 (PIM3)
Type:Protein
Mol. Mass.:35888.19
Organism:Homo sapiens (Human)
Description:Q86V86
Residue:326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
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  Blast E-value cutoff:
BDBM352083
NameBDBM352083
Synonyms:(3R,4R,5S)-3-Amino-1-(3-(((5-fluoro-6-(2-fluoro-6-methoxyphenyl)pyridin-2-yl)methyl)amino)pyridin-4-yl)-5-methylpiperidin-4-ol | US9802918, Example 15
TypeSmall organic molecule
Emp. Form.C24H27F2N5O2
Mol. Mass.455.5003
SMILESCOc1cccc(F)c1-c1nc(CNc2cnccc2N2C[C@H](C)[C@@H](O)[C@H](N)C2)ccc1F |r,wU:26.28,22.24,wD:24.26,(6.72,2.67,;5.38,1.9,;4.05,2.67,;4,4.23,;2.67,5,;1.33,4.23,;1.33,2.69,;,1.93,;2.67,1.92,;2.67,.38,;1.33,-.38,;1.33,-1.92,;,-2.69,;-1.33,-1.92,;-2.67,-2.7,;-2.67,-4.23,;-4,-5,;-5.33,-4.23,;-5.33,-2.7,;-4,-1.93,;-4,-.39,;-2.67,.38,;-2.67,1.92,;-1.33,2.69,;-4,2.69,;-4,4.23,;-5.33,1.92,;-6.67,2.69,;-5.33,.38,;2.67,-2.69,;4,-1.92,;4,-.38,;5.33,.39,)|
Structure
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