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Target
Serine/threonine-protein kinase pim-3
Ligand
BDBM352087
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y; Zhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent  US9802918 Publication Date 10/31/2017 
Target
Name:
Serine/threonine-protein kinase pim-3
Synonyms:
PIM3 | PIM3_HUMAN | Serine/threonine-protein kinase pim-3 (PIM3)
Type:
Protein
Mol. Mass.:
35888.19
Organism:
Homo sapiens (Human)
Description:
Q86V86
Residue:
326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRIADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFLLVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDLRSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVCGDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGVPESCDLRLCTLDPDDVASTTSSSESL
  
Inhibitor
Name:
BDBM352087
Synonyms:
4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-{[6-(2,6-difluorophenyl)-5-fluoropyridin-2-yl]methyl}pyridin-3-amine | US9802918, Example 19
Type:
Small organic molecule
Emp. Form.:
C23H24F3N5
Mol. Mass.:
427.4654
SMILES:
C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cccc1F |r,wU:3.3,1.0,(-.67,2.69,;-2,1.92,;-3.33,2.69,;-4.67,1.92,;-6,2.69,;-4.67,.38,;-3.33,-.39,;-2,.38,;-3.33,-1.93,;-4.67,-2.7,;-4.67,-4.23,;-3.33,-5,;-2,-4.23,;-2,-2.7,;-.67,-1.92,;.67,-2.69,;2,-1.92,;3.33,-2.69,;4.67,-1.92,;4.67,-.38,;6,.39,;3.33,.38,;2,-.38,;3.33,1.92,;2,2.69,;.67,1.93,;2,4.23,;3.33,5,;4.67,4.23,;4.67,2.69,;6,1.93,)|
Structure:
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