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TargetSerine/threonine-protein kinase pim-1
LigandBDBM352093
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50<10±n/a nM
Citation Vechorkin, OLi, YZhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent US9802918 Publication Date 10/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pim-1
Name:Serine/threonine-protein kinase pim-1
Synonyms:PIM-1 Kinase | PIM1 | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:Protein
Mol. Mass.:35681.82
Organism:Homo sapiens (Human)
Description:P11309
Residue:313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM352093
NameBDBM352093
Synonyms:2-(4-{6-[({4-[(3R,4R,5S)-3-Amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}amino)methyl]-3-fluoropyridin-2-yl}-3,5-difluorophenyl)-2-methylpropanenitrile | US9802918, Example 24
TypeSmall organic molecule
Emp. Form.C27H29F3N6O
Mol. Mass.510.554
SMILESC[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C(C)(C)C#N |r,wU:7.8,wD:5.5,1.0,(.99,-.91,;2.32,-1.68,;2.32,-3.22,;3.66,-3.99,;4.99,-3.22,;4.99,-1.68,;6.33,-.91,;3.66,-.91,;3.66,.63,;3.66,-5.53,;4.99,-6.3,;4.99,-7.84,;3.66,-8.61,;2.32,-7.84,;2.32,-6.3,;.99,-5.53,;.99,-3.99,;-.34,-3.22,;-1.68,-3.99,;-3.01,-3.22,;-3.01,-1.68,;-4.34,-.91,;-1.68,-.91,;-.34,-1.68,;-1.68,.63,;-.34,1.4,;.99,.63,;-.34,2.94,;-1.68,3.71,;-3.01,2.94,;-3.01,1.4,;-4.34,.63,;-1.68,5.25,;-.14,5.25,;-3.22,5.25,;-1.68,6.79,;-1.68,8.33,)|
Structure
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