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TargetSerine/threonine-protein kinase pim-2
LigandBDBM352094
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50<100±n/a nM
Citation Vechorkin, OLi, YZhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent US9802918 Publication Date 10/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pim-2
Name:Serine/threonine-protein kinase pim-2
Synonyms:Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase pim-2 (PIM2)
Type:Serine/threonine-protein kinase
Mol. Mass.:34185.93
Organism:Homo sapiens (Human)
Description:Q9P1W9
Residue:311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAI
KVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPL
PAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKL
IDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFER
DQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKG
GPAPLAWSLLP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM352094
NameBDBM352094
Synonyms:2-(4-{6-[({4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]pyridin-3-yl}amino)methyl]-3-fluoropyridin-2-yl}-3,5-difluorophenyl)-2-methylpropanenitrile | US9802918, Example 24A
TypeSmall organic molecule
Emp. Form.C27H29F3N6
Mol. Mass.494.5546
SMILESC[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)C(C)(C)C#N |r,wD:3.3,1.0,(1.19,-.94,;2.52,-1.71,;3.85,-.94,;5.19,-1.71,;6.52,-.94,;5.19,-3.25,;3.85,-4.02,;2.52,-3.25,;3.85,-5.56,;5.19,-6.33,;5.19,-7.87,;3.85,-8.64,;2.52,-7.87,;2.52,-6.33,;1.19,-5.56,;1.19,-4.02,;-.15,-3.25,;-1.48,-4.02,;-2.82,-3.25,;-2.82,-1.71,;-4.15,-.94,;-1.48,-.94,;-.15,-1.71,;-1.48,.6,;-.15,1.37,;1.19,.6,;-.15,2.91,;-1.48,3.68,;-2.82,2.91,;-2.82,1.37,;-4.15,.6,;-1.48,5.22,;.06,5.22,;-3.02,5.22,;-1.48,6.76,;-1.48,8.3,)|
Structure
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