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TargetSerine/threonine-protein kinase pim-3
LigandBDBM352099
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50<10±n/a nM
Citation Vechorkin, OLi, YZhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent US9802918 Publication Date 10/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pim-3
Name:Serine/threonine-protein kinase pim-3
Synonyms:Serine/threonine-protein kinase pim-3 (PIM3)
Type:Protein
Mol. Mass.:35888.19
Organism:Homo sapiens (Human)
Description:Q86V86
Residue:326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM352099
NameBDBM352099
Synonyms:(3R,4R,5S)-3-Amino-1-[3-({[6-(2,6-difluorophenyl)pyridin-2-yl]methyl}amino)pyridin-4-yl]-5-methylpiperidin-4-ol | US9802918, Example 28
TypeSmall organic molecule
Emp. Form.C23H25F2N5O
Mol. Mass.425.4743
SMILESC[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1cccc(n1)-c1c(F)cccc1F |r|
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least:
n/a