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TargetSerine/threonine-protein kinase pim-3
LigandBDBM352117
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50<10±n/a nM
Citation Vechorkin, OLi, YZhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent US9802918 Publication Date 10/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pim-3
Name:Serine/threonine-protein kinase pim-3
Synonyms:Serine/threonine-protein kinase pim-3 (PIM3)
Type:Protein
Mol. Mass.:35888.19
Organism:Homo sapiens (Human)
Description:Q86V86
Residue:326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM352117
NameBDBM352117
Synonyms:(3R,4R,5S)-3-amino-1-(3-(((6-(2,6-difluoro-4-(((R)-3-fluoropyrrolidin-1-yl)methyl)phenyl)-5-fluoropyridin-2-yl)methyl)amino)pyridin-4-yl)-5-methylpiperidin-4-ol | US9802918, Example 46
TypeSmall organic molecule
Emp. Form.C28H32F4N6O
Mol. Mass.544.5869
SMILESC[C@H]1CN(C[C@@H](N)[C@@H]1O)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(CN2CC[C@@H](F)C2)cc1F |r,wU:33.36,5.5,1.0,wD:7.8,(-1.95,.53,;-3.29,-.24,;-3.29,-1.78,;-4.62,-2.55,;-5.96,-1.78,;-5.96,-.24,;-7.29,.53,;-4.62,.53,;-4.62,2.07,;-4.62,-4.09,;-5.96,-4.86,;-5.96,-6.4,;-4.62,-7.17,;-3.29,-6.4,;-3.29,-4.86,;-1.95,-4.09,;-.62,-4.86,;.71,-4.09,;2.05,-4.86,;3.38,-4.09,;3.38,-2.55,;4.71,-1.78,;2.05,-1.78,;.71,-2.55,;2.05,-.24,;3.38,.53,;4.71,-.24,;3.38,2.07,;2.05,2.84,;2.05,4.38,;3.38,5.15,;3.38,6.69,;4.84,7.17,;5.75,5.92,;7.29,5.92,;4.84,4.68,;.71,2.07,;.71,.53,;-.62,-.24,)|
Structure
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