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TargetSerine/threonine-protein kinase pim-1
LigandBDBM352131
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50<10±n/a nM
Citation Vechorkin, OLi, YZhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent US9802918 Publication Date 10/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pim-1
Name:Serine/threonine-protein kinase pim-1
Synonyms:PIM-1 Kinase | PIM1 | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:Protein
Mol. Mass.:35681.82
Organism:Homo sapiens (Human)
Description:P11309
Residue:313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM352131
NameBDBM352131
Synonyms:4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-({6-[2,6-difluoro-4-(4-methoxytetrahydro-2H-pyran-4-yl)phenyl]-5-fluoropyridin-2-yl}methyl)pyridin-3-amine | US9802918, Example 60
TypeSmall organic molecule
Emp. Form.C29H34F3N5O2
Mol. Mass.541.6078
SMILESCOC1(CCOCC1)c1cc(F)c(c(F)c1)-c1nc(CNc2cnccc2N2C[C@H](C)C[C@H](N)C2)ccc1F |r,wU:32.35,29.32,(6,4.23,;4.67,3.46,;3.33,4.23,;2,5,;2,6.54,;3.33,7.31,;4.67,6.54,;4.67,5,;3.33,2.69,;4.67,1.92,;4.67,.38,;6,-.38,;3.33,-.39,;2,.38,;.67,-.39,;2,1.92,;3.33,-1.93,;2,-2.7,;2,-4.24,;.67,-5.01,;-.67,-4.24,;-2,-5,;-2,-6.54,;-3.33,-7.31,;-4.67,-6.54,;-4.67,-5,;-3.33,-4.23,;-3.33,-2.69,;-2,-1.92,;-2,-.38,;-.67,.39,;-3.33,.39,;-4.67,-.38,;-6,.39,;-4.67,-1.92,;3.33,-5.01,;4.67,-4.24,;4.67,-2.7,;6,-1.93,)|
Structure
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