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Target
Serine/threonine-protein kinase pim-1
Ligand
BDBM352139
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<10±n/a nM
Citation
 Vechorkin, O; Li, Y; Zhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent  US9802918 Publication Date 10/31/2017 
Target
Name:
Serine/threonine-protein kinase pim-1
Synonyms:
PIM-1 Kinase | PIM1 | PIM1_HUMAN | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:
Protein
Mol. Mass.:
35681.82
Organism:
Homo sapiens (Human)
Description:
P11309
Residue:
313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSDNLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLILERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDIPFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETAEIHLHSLSPGPSK
  
Inhibitor
Name:
BDBM352139
Synonyms:
4-[(1R,3S,5S)-3-Amino-5-methylcyclohexyl]-N-{[6-(2,6-difluoro-4-morpholin-4-ylphenyl)-5-fluoropyridin-2-yl]methyl}pyridin-3-amine | US9802918, Example 68
Type:
Small organic molecule
Emp. Form.:
C28H32F3N5O
Mol. Mass.:
511.5818
SMILES:
C[C@@H]1C[C@H](N)C[C@@H](C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)N1CCOCC1 |r,wU:6.8,3.3,1.0,(-.67,.38,;-2,-.39,;-3.33,.38,;-4.67,-.39,;-6,.38,;-4.67,-1.93,;-3.33,-2.7,;-2,-1.93,;-3.33,-4.24,;-4.67,-5.01,;-4.67,-6.55,;-3.33,-7.31,;-2,-6.55,;-2,-5.01,;-.67,-4.24,;.67,-5.01,;2,-4.24,;3.33,-5.01,;4.67,-4.24,;4.67,-2.7,;6,-1.93,;3.33,-1.93,;2,-2.7,;3.33,-.39,;4.67,.38,;6,-.39,;4.67,1.92,;3.33,2.69,;2,1.92,;2,.38,;.67,-.39,;3.33,4.23,;4.67,5.01,;4.67,6.55,;3.33,7.31,;2,6.55,;2,5.01,)|
Structure:
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