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Target
Serine/threonine-protein kinase pim-2
Ligand
BDBM352142
Substrate
n/a
Meas. Tech.
Enzyme Assay
IC50
<100±n/a nM
Citation
 Vechorkin, O; Li, Y; Zhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent  US9802918 Publication Date 10/31/2017 
Target
Name:
Serine/threonine-protein kinase pim-2
Synonyms:
PIM2 | PIM2_HUMAN | Pim-2h | Serine/threonine-protein kinase (PIM2) | Serine/threonine-protein kinase PIM | Serine/threonine-protein kinase pim-2 (PIM2)
Type:
Serine/threonine-protein kinase
Mol. Mass.:
34185.93
Organism:
Homo sapiens (Human)
Description:
Q9P1W9
Residue:
311
Sequence:
MLTKPLQGPPAPPGTPTPPPGGKDREAFEAEYRLGPLLGKGGFGTVFAGHRLTDRLQVAIKVIPRNRVLGWSPLSDSVTCPLEVALLWKVGAGGGHPGVIRLLDWFETQEGFMLVLERPLPAQDLFDYITEKGPLGEGPSRCFFGQVVAAIQHCHSRGVVHRDIKDENILIDLRRGCAKLIDFGSGALLHDEPYTDFDGTRVYSPPEWISRHQYHALPATVWSLGILLYDMVCGDIPFERDQEILEAELHFPAHVSPDCCALIRRCLAPKPSSRPSLEEILLDPWMQTPAEDVPLNPSKGGPAPLAWSLLP
  
Inhibitor
Name:
BDBM352142
Synonyms:
4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-({6-[2,6-difluoro-4-(3-fluoropiperidin-1-yl)phenyl]-5-fluoropyridin-2-yl}methyl)pyridin-3-amine | US9802918, Example 71
Type:
Small organic molecule
Emp. Form.:
C28H32F4N6
Mol. Mass.:
528.5875
SMILES:
C[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(cc1F)N1CCCC(F)C1 |r,wU:1.0,3.3,(-.68,.38,;-2.01,-.39,;-3.34,.38,;-4.68,-.39,;-6.01,.38,;-4.68,-1.93,;-3.34,-2.7,;-2.01,-1.93,;-3.34,-4.24,;-4.68,-5.01,;-4.68,-6.54,;-3.34,-7.31,;-2.01,-6.54,;-2.01,-5.01,;-.68,-4.24,;.66,-5.01,;1.99,-4.24,;3.33,-5.01,;4.66,-4.24,;4.66,-2.7,;5.99,-1.93,;3.33,-1.93,;1.99,-2.7,;3.33,-.39,;4.66,.38,;5.99,-.39,;4.66,1.92,;3.33,2.69,;1.99,1.92,;1.99,.38,;.66,-.39,;3.33,4.23,;2.01,5,;2.01,6.54,;3.34,7.31,;4.68,6.54,;6.01,7.31,;4.68,5,)|
Structure:
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