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TargetSerine/threonine-protein kinase pim-1
LigandBDBM352145
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50<10±n/a nM
Citation Vechorkin, OLi, YZhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent US9802918 Publication Date 10/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pim-1
Name:Serine/threonine-protein kinase pim-1
Synonyms:PIM-1 Kinase | PIM1 | Proto-oncogene serine/threonine-protein kinase Pim-1 | Serine/threonine-protein kinase (PIM1) | Serine/threonine-protein kinase PIM1 | Serine/threonine-protein kinase pim-1 (PIM1)
Type:Protein
Mol. Mass.:35681.82
Organism:Homo sapiens (Human)
Description:P11309
Residue:313
Sequence:
MLLSKINSLAHLRAAPCNDLHATKLAPGKEKEPLESQYQVGPLLGSGGFGSVYSGIRVSD
NLPVAIKHVEKDRISDWGELPNGTRVPMEVVLLKKVSSGFSGVIRLLDWFERPDSFVLIL
ERPEPVQDLFDFITERGALQEELARSFFWQVLEAVRHCHNCGVLHRDIKDENILIDLNRG
ELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSAAVWSLGILLYDMVCGDI
PFEHDEEIIRGQVFFRQRVSSECQHLIRWCLALRPSDRPTFEEIQNHPWMQDVLLPQETA
EIHLHSLSPGPSK
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM352145
NameBDBM352145
Synonyms:4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-[(6-{2,6-difluoro-4-[(3R)-tetrahydrofuran-3-yloxy]phenyl}-5-fluoropyridin-2-yl)methyl]pyridin-3-amine | US9802918, Example 74
TypeSmall organic molecule
Emp. Form.C27H30F3N5O2
Mol. Mass.513.5546
SMILESC[C@@H]1C[C@H](N)CN(C1)c1ccncc1NCc1ccc(F)c(n1)-c1c(F)cc(O[C@@H]2CCOC2)cc1F |r,wU:3.3,1.0,29.31,(-1.18,.53,;-2.52,-.24,;-3.85,.53,;-5.19,-.24,;-6.52,.53,;-5.19,-1.78,;-3.85,-2.55,;-2.52,-1.78,;-3.85,-4.09,;-5.19,-4.86,;-5.19,-6.4,;-3.85,-7.17,;-2.52,-6.4,;-2.52,-4.86,;-1.18,-4.09,;.15,-4.86,;1.48,-4.09,;2.82,-4.86,;4.15,-4.09,;4.15,-2.55,;5.48,-1.78,;2.82,-1.78,;1.48,-2.55,;2.82,-.24,;1.48,.53,;.15,-.24,;1.48,2.07,;2.82,2.84,;2.82,4.38,;4.15,5.15,;5.61,4.68,;6.52,5.92,;5.61,7.17,;4.15,6.69,;4.15,2.07,;4.15,.53,;5.48,-.24,)|
Structure
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