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TargetSerine/threonine-protein kinase pim-3
LigandBDBM352151
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
IC50<10±n/a nM
Citation Vechorkin, OLi, YZhuo, J Pyridineamine compounds useful as Pim kinase inhibitors US Patent US9802918 Publication Date 10/31/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Serine/threonine-protein kinase pim-3
Name:Serine/threonine-protein kinase pim-3
Synonyms:Serine/threonine-protein kinase pim-3 (PIM3)
Type:Protein
Mol. Mass.:35888.19
Organism:Homo sapiens (Human)
Description:Q86V86
Residue:326
Sequence:
MLLSKFGSLAHLCGPGGVDHLPVKILQPAKADKESFEKAYQVGAVLGSGGFGTVYAGSRI
ADGLPVAVKHVVKERVTEWGSLGGATVPLEVVLLRKVGAAGGARGVIRLLDWFERPDGFL
LVLERPEPAQDLFDFITERGALDEPLARRFFAQVLAAVRHCHSCGVVHRDIKDENLLVDL
RSGELKLIDFGSGALLKDTVYTDFDGTRVYSPPEWIRYHRYHGRSATVWSLGVLLYDMVC
GDIPFEQDEEILRGRLLFRRRVSPECQQLIRWCLSLRPSERPSLDQIAAHPWMLGADGGV
PESCDLRLCTLDPDDVASTTSSSESL
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  Blast E-value cutoff:
BDBM352151
NameBDBM352151
Synonyms:4-[(3S,5R)-3-Amino-5-methylpiperidin-1-yl]-N-{[6-(2,6-difluoro-4-methoxyphenyl)-5-fluoropyridin-2-yl]methyl}pyridin-3-amine | US9802918, Example 83
TypeSmall organic molecule
Emp. Form.C24H26F3N5O
Mol. Mass.457.4913
SMILESCOc1cc(F)c(c(F)c1)-c1nc(CNc2cnccc2N2C[C@H](C)C[C@H](N)C2)ccc1F |r,wU:23.25,26.28,(4.67,6.16,;3.33,5.39,;3.33,3.85,;2,3.08,;2,1.54,;.67,.77,;3.33,.77,;4.67,1.54,;6,.77,;4.67,3.08,;3.33,-.77,;2,-1.54,;2,-3.08,;.67,-3.85,;-.67,-3.08,;-2,-3.85,;-2,-5.39,;-3.33,-6.16,;-4.67,-5.39,;-4.67,-3.85,;-3.33,-3.08,;-3.33,-1.54,;-2,-.77,;-2,.77,;-.67,1.54,;-3.33,1.54,;-4.67,.77,;-6,1.54,;-4.67,-.77,;3.33,-3.85,;4.67,-3.08,;4.67,-1.54,;6,-.77,)|
Structure
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