Reaction Details Report a problem with these data
Target
Histone deacetylase 8
Ligand
BDBM65543
Substrate
n/a
Meas. Tech.
Enzyme inhibition assay
IC50
1789±n/a nM
Citation
 Zhang, L; Wang, X; Li, X; Zhang, L; Xu, W Discovery of a series of hydroximic acid derivatives as potent histone deacetylase inhibitors. J Enzyme Inhib Med Chem 29:582-9 (2014) [PubMed]  Article 
Target
Name:
Histone deacetylase 8
Synonyms:
HD8 | HDAC8 | HDAC8_HUMAN | HDACL1 | Histone deacetylase 8 (HDAC-8) | Human HDAC8
Type:
Enzyme
Mol. Mass.:
41749.60
Organism:
Homo sapiens (Human)
Description:
Q9BY41
Residue:
377
Sequence:
MEEPEEPADSGQSLVPVYIYSPEYVSMCDSLAKIPKRASMVHSLIEAYALHKQMRIVKPKVASMEEMATFHTDAYLQHLQKVSQEGDDDHPDSIEYGLGYDCPATEGIFDYAAAIGGATITAAQCLIDGMCKVAINWSGGWHHAKKDEASGFCYLNDAVLGILRLRRKFERILYVDLDLHHGDGVEDAFSFTSKVMTVSLHKFSPGFFPGTGDVSDVGLGKGRYYSVNVPIQDGIQDEKYYQICESVLKEVYQAFNPKAVVLQLGADTIAGDPMCSFNMTPVGIGKCLKYILQWQLATLILGGGGYNLANTARCWTYLTGVILGKTLSSEIPDHEFFTAYGPDYVLEITPSCRPDRNEPHRIQQILNYIKGNLKHVV
  
Inhibitor
Name:
BDBM65543
Synonyms:
(S)-4-(3-(2-((2,6-diisopropylphenyl)amino)-2-oxo-1-phenylethyl)ureido)-N-(6-(hydroxyamino)-6-oxohexyl)benzamide (L17)
Type:
Small Organic Molecule
Emp. Form.:
C34H43N5O5
Mol. Mass.:
601.7357
SMILES:
CC(C)c1cccc(C(C)C)c1NC(=O)[C@@H](NC(=O)Nc1ccc(cc1)C(=O)NCCCCCC(=O)NO)c1ccccc1
Structure:
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