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Target
Gamma-aminobutyric acid receptor subunit alpha-2
Ligand
BDBM352399
Substrate
n/a
Meas. Tech.
Binding Assay
Ki
54.7±n/a nM
Citation
 Owen, RM; Pryde, DC; Takeuchi, M; Watson, CA Imidazopyridazine derivatives as modulators of the GABAA receptor activity US Patent  US9802945 Publication Date 10/31/2017 
Target
Name:
Gamma-aminobutyric acid receptor subunit alpha-2
Synonyms:
GABA receptor alpha-2 subunit | GABRA2 | GBRA2_HUMAN | Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2)
Type:
Protein
Mol. Mass.:
51338.78
Organism:
Homo sapiens (Human)
Description:
P47869
Residue:
451
Sequence:
MKTKLNIYNMQFLLFVFLVWDPARLVLANIQEDEAKNNITIFTRILDRLLDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMNILRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPMHLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKETIKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGKSVVNDKKKEKASVMIQNNAYAVAVANYAPNLSKDPVLSTISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATYLNREPVLGVSP
  
Inhibitor
Name:
BDBM352399
Synonyms:
5-[5-(7-Cyclopropyl-7H-imidazo[4,5-c]pyridazin-4-yl)-2-fluorophenyl]-2-methyl-2,3-dihydro-1H-isoindol-1-one | US9802945, 10
Type:
Small organic molecule
Emp. Form.:
C23H18FN5O
Mol. Mass.:
399.4203
SMILES:
CN1Cc2cc(ccc2C1=O)-c1cc(ccc1F)-c1cnnc2n(cnc12)C1CC1
Structure:
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