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Target
Cathepsin K
Ligand
BDBM352417
Substrate
n/a
Meas. Tech.
Enzyme Assay
Ki
2.10±n/a nM
Citation
 Nardi, A; Ratcliffe, P; Craan, T; Hertrampf, T; Lesch, B; Steinhagen, H 3-oxo-tetrahydro-furo[3,2-b]pyrrol-4(5H)-yl) derivatives II US Patent  US9802947 Publication Date 10/31/2017 
Target
Name:
Cathepsin K
Synonyms:
CATK_HUMAN | CTSK | CTSO | CTSO2 | Cathepsin O | Cathepsin O2 | Cathepsin X
Type:
Enzyme
Mol. Mass.:
36975.68
Organism:
Homo sapiens (Human)
Description:
P43235
Residue:
329
Sequence:
MWGLKVLLLPVVSFALYPEEILDTHWELWKKTHRKQYNNKVDEISRRLIWEKNLKYISIHNLEASLGVHTYELAMNHLGDMTSEEVVQKMTGLKVPLSHSRSNDTLYIPEWEGRAPDSVDYRKKGYVTPVKNQGQCGSCWAFSSVGALEGQLKKKTGKLLNLSPQNLVDCVSENDGCGGGYMTNAFQYVQKNRGIDSEDAYPYVGQEESCMYNPTGKAAKCRGYREIPEGNEKALKRAVARVGPVSVAIDASLTSFQFYSKGVYYDESCNSDNLNHAVLAVGYGIQKGNKHWIIKNSWGENWGNKGYILMARNKNNACGIANLASFPKM
  
Inhibitor
Name:
BDBM352417
Synonyms:
N—((S)-2-((3aS,6S,6aS)-6-chloro-3-oxotetrahydro-2H-furo[3,2-b]pyrrol-4(5H)-yl)-1-cyclopentyl-2-oxoethyl)-5-(pyrazin-2-yl)thiophene-2-carboxamide | US9802947, Compound Example 5
Type:
Small organic molecule
Emp. Form.:
C22H23ClN4O4S
Mol. Mass.:
474.96
SMILES:
Cl[C@H]1CN([C@H]2[C@@H]1OCC2=O)C(=O)[C@@H](NC(=O)c1ccc(s1)-c1cnccn1)C1CCCC1 |r|
Structure:
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