Reaction Details Report a problem with these data
Target
Coagulation factor IX
Ligand
BDBM352451
Substrate
n/a
Meas. Tech.
Inhibitory Activity Assay
IC50
<100±n/a nM
Citation
 Sakurada, I; Hirabayashi, T; Maeda, Y; Nagasue, H; Mizuno, T; Xu, J; Zhang, T; Smith, C; Parker, D Factor IXa inhibitors US Patent  US9808445 Publication Date 11/7/2017 
Target
Name:
Coagulation factor IX
Synonyms:
Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:
Enzyme
Mol. Mass.:
51768.83
Organism:
Homo sapiens (Human)
Description:
P00740
Residue:
461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
  
Inhibitor
Name:
BDBM352451
Synonyms:
N-((1S*,4S*,7R*)-2-(3-Amino-5-methylisoxazolo[5,4-c]pyridin-7-yl)-2-azabicyclo[2.2.1]heptan-7-yl)-2-chloro-4-(3-(trifluoromethyl)-4H-1,2,4-triazol-4-yl)benzamide | US9808445, 26
Type:
Small organic molecule
Emp. Form.:
C23H20ClF3N8O2
Mol. Mass.:
532.906
SMILES:
Cc1cc2c(N)noc2c(n1)N1CC2CCC1C2NC(=O)c1ccc(cc1Cl)-n1cnnc1C(F)(F)F
Structure:
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