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Target
Coagulation factor IX
Ligand
BDBM352460
Substrate
n/a
Meas. Tech.
Factor XIa Assay
Ki
<5.00±n/a nM
Citation
 Ogawa, A; Edmondson, S; Erion, M; Neelamkavil, S; Guo, Z; Mal, R; He, J; Liu, W; Vande Bunte, EK Factor XIa inhibitors US Patent  US9809545 Publication Date 11/7/2017 
Target
Name:
Coagulation factor IX
Synonyms:
Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:
Enzyme
Mol. Mass.:
51768.83
Organism:
Homo sapiens (Human)
Description:
P00740
Residue:
461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
  
Inhibitor
Name:
BDBM352460
Synonyms:
US9809545, 1Ef
Type:
Small organic molecule
Emp. Form.:
C28H21ClN6O4
Mol. Mass.:
540.957
SMILES:
OC(=O)c1ccc(NC(=O)[C@H](Cc2ccccc2)n2ccc(cc2=O)-c2cc(Cl)ccc2-n2cnnn2)cc1
Structure:
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