Reaction Details Report a problem with these data
Target
Coagulation factor IX
Ligand
BDBM352466
Substrate
n/a
Meas. Tech.
Factor XIa Assay
Ki
<5.00±n/a nM
Citation
 Ogawa, A; Edmondson, S; Erion, M; Neelamkavil, S; Guo, Z; Mal, R; He, J; Liu, W; Vande Bunte, EK Factor XIa inhibitors US Patent  US9809545 Publication Date 11/7/2017 
Target
Name:
Coagulation factor IX
Synonyms:
Christmas factor | Coagulation factor IX precursor | Coagulation factor IX/VIII | Coagulation factor IXa | Coagulation factor IXa heavy chain | Coagulation factor IXa light chain | F9 | FA9_HUMAN | Factor IX | Factor IXa | Factor IXa (fIXa) | PTC | Plasma thromboplastin component
Type:
Enzyme
Mol. Mass.:
51768.83
Organism:
Homo sapiens (Human)
Description:
P00740
Residue:
461
Sequence:
MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKILNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFENTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECWCPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSCTEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVFPDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKPGQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVKITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYNHDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGYVSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIYNNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIISWGEECAMKGKYGIYTKVSRYVNWIKEKTKLT
  
Inhibitor
Name:
BDBM352466
Synonyms:
US9809545, 3Bd
Type:
Small organic molecule
Emp. Form.:
C28H19ClFN7O3
Mol. Mass.:
555.947
SMILES:
OC(=O)c1ccc2[nH]c(nc2c1)[C@H](Cc1ccc(F)cc1)n1ccc(cc1=O)-c1cc(Cl)ccc1-n1cnnn1
Structure:
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