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TargetApoptosis regulator Bcl-2
LigandBDBM353026
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarisation Assay
IC50 2.60±n/a nM
Citation Davidson, JEMurray, JBChen, IWalmsley, CDodsworth, MMeissner, JWBrough, PFejes, ITatai, JNyerges, MKotschy, ASzlávik, ZGeneste, OLe Tiran, ALe Diguarher, THenlin, JStarck, JGuillouzic, ADe Nanteuil, G Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them US Patent US9809574 Publication Date 11/7/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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  Blast E-value cutoff:
BDBM353026
NameBDBM353026
Synonyms:N-(4-Hydroxyphenyl)-5-{2-[2-(4-methoxyphenyl)acetyl]-6-[(3R)-3-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]-2,3-dihydro-1H-isoindol-5-yl}-N,1,2-trimethyl-1H-pyrrole-3-carboxamide | US9809574, Example 101
TypeSmall organic molecule
Emp. Form.C42H42N4O5
Mol. Mass.682.8067
SMILESCOc1ccc(CC(=O)N2Cc3cc(C(=O)N4Cc5ccccc5C[C@H]4C)c(cc3C2)-c2cc(C(=O)N(C)c3ccc(O)cc3)c(C)n2C)cc1
Structure
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