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Target
Apoptosis regulator Bcl-2
Ligand
BDBM353033
Substrate
n/a
Meas. Tech.
Fluorescence Polarisation Assay
IC50
2.70±n/a nM
Citation
 Davidson, JE; Murray, JB; Chen, I; Walmsley, C; Dodsworth, M; Meissner, JW; Brough, P; Fejes, I; Tatai, J; Nyerges, M; Kotschy, A; Szlávik, Z; Geneste, O; Le Tiran, A; Le Diguarher, T; Henlin, J; Starck, J; Guillouzic, A; De Nanteuil, G Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them US Patent  US9809574 Publication Date 11/7/2017 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM353033
Synonyms:
3-{2-[2-(4-{[2-(Dimethylamino)ethyl]amino}phenyl)acetyl]-7-[(3R)-3-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]-1,2,3,4-tetrahydroisoquinolin-6-yl}-N-(4-hydroxyphenyl)-N-methyl-5,6,7,8-tetrahydroindolizine-1-carboxamide hydrochloride | US9809574, Example 108
Type:
Small organic molecule
Emp. Form.:
C48H54N6O4
Mol. Mass.:
778.9802
SMILES:
C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2CN(CCc2cc1-c1cc(C(=O)N(C)c2ccc(O)cc2)c2CCCCn12)C(=O)Cc1ccc(NCCN(C)C)cc1
Structure:
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