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Target
Apoptosis regulator Bcl-2
Ligand
BDBM354582
Substrate
n/a
Meas. Tech.
Fluorescence Polarisation Assay
IC50
3.40±n/a nM
Citation
 Davidson, JE; Murray, JB; Chen, I; Walmsley, C; Dodsworth, M; Meissner, JW; Brough, P; Fejes, I; Tatai, J; Nyerges, M; Kotschy, A; Szlávik, Z; Geneste, O; Le Tiran, A; Le Diguarher, T; Henlin, J; Starck, J; Guillouzic, A; De Nanteuil, G Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them US Patent  US9809574 Publication Date 11/7/2017 
Target
Name:
Apoptosis regulator Bcl-2
Synonyms:
Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein
Type:
Homodimer or heterodimer
Mol. Mass.:
26269.11
Organism:
Homo sapiens (Human)
Description:
P10415
Residue:
239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPAASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLHLTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEYLNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
  
Inhibitor
Name:
BDBM354582
Synonyms:
5-{2-[2-(2H-1,3-Benzodioxol-5-yl)acetyl]-6-[(3R)-3-methyl-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]-2,3-dihydro-1H-isoindol-5-yl}-N-(4-hydroxyphenyl)-N,1,2-trimethyl-1H-pyrrole-3-carboxamide | US9809574, Example 172
Type:
Small organic molecule
Emp. Form.:
C42H40N4O6
Mol. Mass.:
696.7902
SMILES:
C[C@@H]1Cc2ccccc2CN1C(=O)c1cc2CN(Cc2cc1-c1cc(C(=O)N(C)c2ccc(O)cc2)c(C)n1C)C(=O)Cc1ccc2OCOc2c1
Structure:
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