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TargetApoptosis regulator Bcl-2
LigandBDBM354612
Substrate/Competitorn/a
Meas. Tech.Fluorescence Polarisation Assay
IC50 2.50±n/a nM
Citation Davidson, JEMurray, JBChen, IWalmsley, CDodsworth, MMeissner, JWBrough, PFejes, ITatai, JNyerges, MKotschy, ASzlávik, ZGeneste, OLe Tiran, ALe Diguarher, THenlin, JStarck, JGuillouzic, ADe Nanteuil, G Isoindoline or isoquinoline compounds, a process for their preparation and pharmaceutical compositions containing them US Patent US9809574 Publication Date 11/7/2017  Article
More Info.:Get all data from this article,  Assay Method
 
Apoptosis regulator Bcl-2
Name:Apoptosis regulator Bcl-2
Synonyms:Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | Bcl-2 Protein
Type:Homodimer or heterodimer
Mol. Mass.:26269.11
Organism:Homo sapiens (Human)
Description:P10415
Residue:239
Sequence:
MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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  Blast E-value cutoff:
BDBM354612
NameBDBM354612
Synonyms:4-Methylphenyl 6-{1,5-dimethyl-4-[methyl(phenyl)carbamoyl]-1H-pyrrol-2-yl}-7-[(3S)-3-(morpholin-4-ylmethyl)-1,2,3,4-tetrahydroisoquinoline-2-carbonyl]-1,2,3,4-tetrahydroisoquinoline-2-carboxylate | US9809574, Example 591
TypeSmall organic molecule
Emp. Form.C46H49N5O5
Mol. Mass.751.9118
SMILESCN(C(=O)c1cc(-c2cc3CCN(Cc3cc2C(=O)N2Cc3ccccc3C[C@H]2CN2CCOCC2)C(=O)Oc2ccc(C)cc2)n(C)c1C)c1ccccc1
Structure
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